The biological heterogeneity and disseminated presentation of follicular lymphoma makes it difficult to select a site for biopsy. The cells can spread into the blood and bone marrow. When you have follicular lymphoma, the sick blood cells can travel to many parts of your body, such as your organs, bone marrow, and lymph nodes peasized glands in your neck, groin, and under. New perspectives in treatment strategies for follicular lymphoma last modified by. Powerpoint is the worlds most popular presentation software which can let you create professional about leukemia powerpoint presentation easily and in no time. Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma michael r. Follicular lymphoma fl is a cancer that involves certain types of white blood cells known as lymphocytes. Pfl shows a male predominance with median age of onset varying from 7. Our experience with fl grade 3a, compared with fl grade 3b or with concomitant diffuse large b cell lymphoma, primarily treated with rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone suggests possible. The updated esmo clinical practice guidelines on newly diagnosed and relapsed follicular lymphoma cover diagnosis, staging and risk assessment. New perspectives in treatment strategies for follicular. The two major types of lymphoma are hodgkin lymphoma hl and nonhodgkin lymphoma nhl.
L follicular lymphoma 306 22 l chronic lymphocytic leukemia 88 6 i mantle cell lymphoma 83 6 l marginal zone bcell lymphoma,malttype 72 5 l marginal zone bcell lymphoma,nodal 20 1 l lymphoplasmacytic lymphoma 15 1 h burkitt lymphoma 10 20. Autologous stem cell transplantation for follicular lymphoma. New perspectives in treatment strategies for follicular lymphoma. Powerpoint is the worlds most popular presentation software which can let you create professional non hodgkin lymphoma powerpoint presentation easily and in no time. Disease management of the four largest bcell nhl indications, which includes diffuse large bcell lymphoma. Apr 04, 2019 follicular lymphoma fl is the most common indolent nonhodgkin lymphoma nhl, representing 20% to 30% of all cases. We assessed the role of highdose therapy and autologous stem cell transplantation asct in transplanteligible patients. Our experience with fl grade 3a, compared with fl grade 3b or with concomitant diffuse large b cell lymphoma, primarily treated with rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone. Bendamustine plus rituximab versus chop plus rituximab as. It is the most common of the clinically indolent nhls defined as those lymphomas in which survival of the untreated patient is measured in years.
Follicular lymphoma is a slowgrowing disease exhibiting a heterogeneous clinical course, with a subset of patients experiencing a rapid disease course in the first two years and some developing. Follicular lymphoma is a cancer that develops in the white blood cells, lymphatic system and bone marrow. Lymphoma, or lymphatic cancer, is a broad term encompassing a variety of cancers of the lymphatic system. Lymphoma is a general name for a group of cancers that affect the lymphatic system. How i treat earlyrelapsing follicular lymphoma blood. Bendamustine plus rituximab is effective for relapsed or refractory disease. Free download follicular lymphoma powerpoint presentation slides. Clustering analysis reveals an immune signature with reduced expression of costimulatory molecules on intratumoral t. The nccn guidelines panel for cervical cancer screening endorses the following guidelines for the prevention and early detection of cervical cancer. Follicular lymphoma fl is the most common indolent nonhodgkin lymphoma.
Pfl most commonly occurs in the head and neck region arising in lymph nodes or lymphoid tissue of waldeyers ring. In 20, about 731,277 people were either living with, or in remission from, lymphoma. Seom clinical guidelines for the treatment of follicular non. Autologous stem cell transplantation for follicular. Follicular lymphoma fl is the second most common type of nonhodgkin lymphoma nhl.
Myron czuczman on lymphoma and lenalidomide youtube imedex ash 20. The disorder is characterized by tumor cells which look circular or clumplike when viewed under the microscope. Lacasce, md video presentation lymphoma at ash 20 bmt grand rounds imedex 20. Clinical implications of cd30 expression in aggressive b. Systemic symptoms like fever, night sweats and weight loss is not seen at presentation most of the time but it can be seen in later stages of the disease progression to an intermediategrade or highgrade lymphoma is considered as soon as a patient develops any systemic symptoms. Slides from presentations at icml 20 and transcribed comments from a recent interview with jonathan w friedberg, md, mmsc 719. This helps you give your presentation on non hodgkin lymphoma in a conference, a school lecture, a business proposal, in a webinar and business and professional representations the uploader spent hisher valuable time to create. Follicular lymphoma fl is an indolent disease but can undergo transformation to a fatal malignancy, typically diffuse large b cell lymphoma dlbcl.
What is follicular lymphoma european society for medical. In follicular lymphoma and mantle cell lymphoma, prolongation of overall survival has been demonstrated over the last several decades, attributed in part to the introduction of the anticd20 monoclonal antibody rituximab to standard. Burkitts lymphoma, t1418 follicular lymphoma, and t1114 mantle cell lymphoma. Follicular lymphomas are the second most frequent subtype of nodal lymphoid malignancies in western europe. Hierarchy in somatic mutations arising during genomic. The 2016 world health organization who classification has categories for rare types of lowgrade bcell lymphomas affecting children and young adults that include pediatrictype follicular lymphoma ptfl, pediatric nodal marginal zone lymphoma pnmzl, and pediatric extranodal marginal zone lymphoma of mucosaassociated lymphoid tissue. The annual incidence of this disease is rare but has increased during recent decades.
Seom clinical guidelines for the treatment of follicular. The cancer originates from the uncontrolled division of specific types of bcells known as centrocytes and centroblasts. Follicular lymphomas typically show no such polarization occasionally seen in grade 2 follicular lymphoma. A pediatrictype follicular lymphoma with marginal zone. Over the past 30 years, highdose chemotherapy supported by autologous stem cell transplantation hdtasct has been frequently used in eligible patients with follicular lymphoma fl requiring treatment, and has been explored as part of consolidation therapy in first remission 15 and in the relapsed setting 6,7 along with conventional chemotherapy, radiotherapy, and anticd20. We analyzed 162 patients with advancedstage fl who had. Feb 28, 20 hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma michael r. Mar 03, 2020 of the more than 66,000 cases of nonhodgkin lymphoma nhl estimated to have been diagnosed in 2008 in the united states, 1520% were follicular lymphomas. Highgrade lymphoma with myc and bcl2 rearrangement. Rituximab plus chemotherapy, most often chop cyclophosphamide, doxorubicin, vincristine, and prednisone, is the firstline standard of care for patients with advanced indolent lymphoma, and for elderly patients with mantlecell lymphoma. Autologous stem cell transplantation for patients with early.
Powerpoint is the worlds most popular presentation software which can let you create professional follicular lymphoma powerpoint presentation easily and in no time. Follicular lymphoma is a welldefined subtype of nonhodgkin lymphoma nhl with cells of the lymphoid tissues in the lymphatic system multiplying uncontrollably to eventually cause tumours to. Microabstractus food and drug administration approval of brentuximab for treatment of cd30positive relapsedrefractory lymphomas initiated research focused on cd30 expression in lymphomas. It is considered the prototype of indolent bcell lymphomas, being generally incurable and characterised by waxing and waning disease with slow progression. Mitotic figures less frequent in follicular lymphoma than reactive hyperplasia. Improvements in observed and relative survival in follicular. The goal of this activity is to educate clinicians on key prognostic and clinical factors to be considered when selecting treatment for patients with follicular lymphoma, as well as the benefits and risks of current and emerging evidencebased treatment strategies in the firstline, consolidation. Clinical implications of cd30 expression in aggressive bcell. Follicular lymphoma affects bcell lymphocytes and is indolent, which means it grows very slowly. Free download about leukemia powerpoint presentation slides. Calgb50803 and relevance trials of lenalidomide and. This helps you give your presentation on follicular lymphoma in a conference, a school lecture, a business proposal, in a webinar and business and professional representations the uploader spent hisher valuable time to create. Follicular lymphoma is a welldefined subtype of nonhodgkin lymphoma nhl with cells of the lymphoid tissues in the lymphatic system multiplying uncontrollably to eventually cause tumours to grow.
The world health organization who is preparing a revised and updated edition of the 2008 classification of tumors of the hematopoietic and lymphoid tissue to be released in 2017. These cells normally occupy the follicles nodular swirls of various types of lymphocytes in the germinal centers of. Follicular lymphoma is characterised by a relapsing and remitting disease course that may undergo transition to a more aggressive disease. Microabstractwhether to clinically approach follicular lymphoma fl grade 3 as an indolent or aggressive lymphoma, especially since the introduction of rituximab, is unclear. Follicular lymphoma fl is the most common indolent nonhodgkin lymphoma nhl, representing 20% to 30% of all cases. In the united states in 20, about 9,290 persons were expected to be diagnosed with hodgkin lymphoma. Free download follicular lymphoma powerpoint presentation. The introduction of targeted agents for the treatment of nonhodgkin lymphoma has resulted in substantial improvements in patient outcomes. Chemo is the main treatment for most people with nonhodgkin lymphoma nhl. Autologous stem cell transplantation for patients with. Hodgkins and non hodgkins lymphoma aprof graham young senior staff specialist institute of haematology royal prince alfred hospital sydney slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Mar 29, 2018 patients with follicular lymphoma fl and progression of disease pod within 24 months after frontline treatment pod24 have poor overall survival os. Nonhodgkins bcell lymphoma opportunity analysis and forecast to 2018 the competitive landscape in the bcell nhl markets in the us, france, italy, germany, spain and the uk is poised to undergo a dramatic shift during the forecast period.
These cells normally occupy the follicles nodular swirls of various types of lymphocytes in the germinal centers of lymphoid tissues such as lymph nodes. Pasqualucci, dallafavera, and colleagues now find that the dominant clone of fl and transformed fl tfl arise by divergent evolution from a common mutated precursor through distinct genetic events, including cdkn2ab loss, myc deregulation. The 2016 updated who classification of lymphoid neoplasias. The two main groups of lymphoma in humans are hodgkin lymphoma hl, also known as hodgkin disease, and the nonhodgkin lymphoma hodgkin lymphoma, named for thomas hodgkin, a british physician who identified it in 1832, is a rare cancer and accounts for only. Histogenetically, follicular lymphoma arises from germinal centre b cells.
This activity is intended for hematologists and oncologists. Follicular lymphoma fl is the most common type of indolent nhl. Updates on treatment strategies daryl tan raffles cancer center visiting consultant singapore general hospital adjunct assistant pr slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Feb 24, 2014 the uploader spent hisher valuable time to create this follicular lymphoma powerpoint presentation slides, to share hisher useful content with the world. The optimal salvage treatment for these patients is unknown. Ppt gastrointestinal lymphomas powerpoint presentation. Chemoimmunotherapy is effective in treating fl and rituximab, an anticd20 antibody ab, combined with chemotherapy including bendamustine or chop has significantly improved outcomes. Like most lymphomas, follicular lymphoma usually begins in the lymph nodes. Rituximab maintenance treatment for a maximum of 5 years in follicular lymphoma. The uploader spent hisher valuable time to create this non hodgkin lymphoma powerpoint presentation slides, to share hisher useful content with the world. Free download non hodgkin lymphoma powerpoint presentation. Discuss the basis of the classification of lymphomas know.
We studied cd30 expression in various types of previously unstudied aggressive bcell lymphomas, including burkitt lymphoma, highgrade follicular lymphoma, grade iii follicular lymphomadiffuse large b. Depending on the type1 and the stage2 of the lymphoma, chemo may be used alone or combined with other treatments, such as immunotherapy drugs orradiation therapy. Fl is the second most frequent lymphoma subtype, and in recent decades, the incidence has risen to 57 cases per 100,000 people and represents approximately 20 % of all lymphomas. The follicular lymphoma international prognostic index flipi was low. As a lowgrade tumour, it is the most commonly occurring subtype among indolent b cell lymphomas in the western world 1, 2. The uploader spent hisher valuable time to create this follicular lymphoma powerpoint presentation slides, to share hisher useful content with the world. Factors for determining treatment after you are diagnosed with follicular lymphoma, your doctor may run blood tests, bone marrow tests and ct andor pet scans. Paediatric follicular lymphoma diagnostic histopathology. Free download non hodgkin lymphoma powerpoint presentation slides. Other internal organs, including the liver and spleen, may also be affected. In follicular lymphoma and mantle cell lymphoma, prolongation of overall survival has been demonstrated over the last several decades, attributed in part to the introduction of the anticd20 monoclonal antibody rituximab to standard chemotherapy. In addition, there is a risk for transformation to an aggressive lymphoma of. Malignant lymphoma malignant lymphoma tom koz k lecture, pregradual, summer semester 20 3rd faculty of medicine, charles university in prague powerpoint ppt presentation free to view lymphoma lymphoma dr.
Treating nonhodgkin lymphoma american cancer society. We studied cd30 expression in various types of previously unstudied aggressive bcell lymphomas, including burkitt lymphoma, highgrade follicular lymphoma, grade iii follicular lymphoma diffuse large b. Learning about follicular lymphoma treatment approaches and ways to manage side effects will help you feel empowered and improve your quality of life. Follicular non hodgkins lymphoma fl is a nodal b lymphoid malignancy that originates from the germinal centre of a lymph node. American cancer society, american society for colposcopy and cervical pathology, and american society for clinical pathology screening guidelines for the prevention and early detection of cervical cancer. This helps you give your presentation on about leukemia in a conference, a school lecture, a business proposal, in a webinar and business and professional representations the uploader spent hisher valuable time to create this about. Follicular lymphoma fl is the second most common subtype of nonhodgkin lymphoma. A free powerpoint ppt presentation displayed as a flash slide show on id. Mar 14, 2017 the introduction of targeted agents for the treatment of nonhodgkin lymphoma has resulted in substantial improvements in patient outcomes. Which chemo drugs are used to treat nonhodgkin lymphoma. Its important to weigh the benefits of each treatment option against the possible risks and side effects.
This number includes about 172,937 people with hodgkin lymphoma about 558,340 people with nonhodgkin lymphoma the lymphoma guide has sections with information for all types of lymphoma, for hodgkin lymphoma and for nonhodgkin lymphoma. Irish, 1, 4 shingo kihira, 1 chih long liu, 1 itai kela, 1 erik s. Jan 21, 2009 hodgkins and non hodgkins lymphoma aprof graham young senior staff specialist institute of haematology royal prince alfred hospital sydney slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Raid jastania dec 2006 by the end of this session you should be able to. In most cases, follicular lymphoma shows a painless, slow and progressive adenopathy 9. Paediatric follicular lymphoma pfl is a rare variant of follicular lymphoma accounting for approximately 1%2% of all paediatric nonhodgkin lymphomas. Follicular lymphoma fl is the most common type of small cell bcell lymphoma, accounting for approximately 30% of all bcell lymphomas. The two main groups of lymphoma in humans are hodgkin lymphoma hl, also known as hodgkin disease, and the nonhodgkin lymphoma. Download the pdf esmomagnitude of clinical benefit scale clinical practice guidelines consensus.
Impact of concurrent indolent lymphoma on the clinical outcome of newly diagnosed diffuse large bcell lymphoma. Progress in the management of follicular lymphoma fl has. It is considered the prototype of indolent bcell lymphomas, being generally incurable and characterised by. It is one of the most common forms of nonhodgkin lymphoma. Ppt lymphoma powerpoint presentation free to download. The translocation results in deregulation of the bcl2 protooncogene, which confers a survival advantage to the affected cells by preventing apoptotic death. Factors for determining treatment after you are diagnosed with follicular lymphoma, your doctor may run blood tests, bone marrow tests and ct. Follicular lymphoma fl is an indolent b cell malignancy characterized by an extensive but poorly functional t cell infiltrate in the tumor microenvironment. Patients with follicular lymphoma fl and progression of disease pod within 24 months after frontline treatment pod24 have poor overall survival os.
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